This adaptive reuse project transformed 63,000 square feet of a 19^th century industrial building into a 21^st century research facility for SQZ Biotech (“Squeeze”). Daylight entering through ample skylights and windows satisfies most lighting needs during the day. On cloudy days and after dark, a bold lighting solution provides general lighting throughout by indirectly lighting the high sloped ceilings, avoiding the clutter and complexity of hanging fixtures throughout the large volumes. Additional illuminance levels at the lab benches are provided by a unique, integrated bench lighting system. Overall lighting power density for the project, approximately half-lab and half-office, is only 0.45 w/ft2, resulting in a $39,697 Mass Save Performance Lighting incentive payment to the owner.